ABSTRACT
AIM:To compare the efficacy of one initial intravitreal Conbercept injection(IVR) followed by pro re nata(PRN) dosing with that of three initial monthly IVR followed by PRN dosing in patients with macular edema (ME) after branch retinal vein occlusion (BRVO). METHODS: The clinical data of 35 cases were retrospectively analyzed; 20 received one initial IVR injection (1+PRN group) and 15 cases received 3-monthly IVRs (3+PRN). Both groups were followed monthly for 12mo. The best-corrected visual acuity (BCVA) and the macular central retinal thickness (CMT) on optical coherence tomography were evaluated before and after treatment, and the BCVA results were converted to the LogMAR visual acuity. RESULTS: The mean LogMAR BCVA and CMT, respectively,improved from 0.58士0.21 to 0.34士0.18 and from 561士65μ m to 252士69μ m in the"1+PRN冶 group (P<0 05) and from 0.64士0.21 to 0.29士0.13 and from 585士87μ m to 242士56μ m in the"3+PRN冶 group (P>0.05). During the study period, the mean total number of injections was significantly smaller in the"1+PRN冶 group than in the"3+PRN冶 group (2. 3士1. 2 and 4. 1士1. 1, respectively,P<0.05). No serious complications related to the IVB injections developed in either group. CONCLUSION: The two methods are both safe and effective for the treatment of BRVO combined with ME.
ABSTRACT
AIM: To analyze the effect of intravitreal injection of Conbercept before pars plana vitrectomy (PPV) on complications and visual recovery in patients with proliferative diabetic retinopathy (PDR). METHODS: Totally 94 patients with PDR (monocular onset) were randomly divided into the experimental group (n=47) and the control group(n=47). All patients were treated by PPV. The experimental group was treated with intravitreal injection of conbercept at 5-7d before PPV while the control group was not given the intervention. The surgical time,surgical procedures,complications and visual recovery in the two groups were observed and statistically analyzed. RESULTS: The operating time of PPV for the experimental group was significantly shorter than that for the control group(72.33士15.71min vs 91.06士19.29min,P<0. 05). The incidence rates of intraoperative electric coagulation hemostasis, iatrogenic breaks and hemorrhage of new vessels in the experimental group (4%,2% and 6%) were significantly lower than those in the control group (19%, 15% and 26%; P<0.05). The mean Log Mar acuity BCVA and the macular thickness decreased significantly of the two groups at 3mo and 6mo after surgery (P<0.05). The improvement effect in the experimental group was better than that in the control group (P<0.05). CONCLUSION: The intravitreal injection of conbercept before PPV has a positive effect on reducing the incidence of intraoperative complications and promoting postoperative visual recovery in patients with PDR.